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Set at the height of the plague in London in 1665, One Flea Spare follows a mysterious orphaned girl and a runaway sailor who sneak into the home of a wealthy couple. Forced to quarantine together for 28 days - under threat of death by the swindling, opportunistic guard outside of the window - the home's inhabitants test the limits of authority, the power of alliances, and the sexual implications of fruit. As confinement grows untenable, a single question lingers: Who will make it out alive?